Glucosamine is a building block of connective tissue, while chondroitin helps cartilage retain water so it stays flexible. Together they soothe sore joints. A study in the New England Journal of Medicine reports that 79 percent of men who took 1,500 mg glucosamine and 1,200 mg chondroitin daily felt a significant reduction in chronic knee pain. Glucosamine-chondroitin supplements take longer to work than NSAIDs (non-steroidal pain killers like aspirin and ibuprofen), but have fewer side effects and last longer. Russian researchers also found that chondroitin reduces back pain.
Conditions: Knee pain, Back pain
Recommendations: Try 2 to 3 capsules of Cosamin DS daily
Interactions & Side Effects: Shellfish allergy. Reactions are rare but if you’re allergic to shellfish (glucosamine is made from shellfish shells), check with your healthcare provider before you take the supplement, or try a vegetarian version. Insulin -- May reduce effectiveness
Source: Men's Health